Changes in Gene Expression and Neuroinflammation in the Hippocampus after Focal Brain Ischemia: Involvement in the Long-Term Cognitive and Mental Disorders

Abstract Ischemic brain injuries are accompanied by the long-term changes in gene expression hippocampus, limbic system structure, involved regulation of key aspects higher nervous activity, such as cognitive functions and emotions. The altered genes proteins encoded them may be related to development post-ischemic psycho-emotional disturbances. Activation neuroinflammation following stroke hippocampus has been suggested play an essential role induction long-lasting consequences. Identification patterns after ischemia investigation dynamics these necessary first steps toward understanding molecular pathways responsible for post-stroke impairments mental pathologies.